Multivariate Normally Distributed Biomarkers Subject to Limits of Detection and Receiver Operating Characteristic Curve Inference

Application of adjusted-receiver operating characteristic curve analysis in combination of biomarkers for early detection of gestational diabetes mellitus

Introduction: In medical diagnostic field, evaluation of diagnostic accuracy of biomarkers or tests has always been a matter of concern. In some situations, one biomarker alone may not be sufficiently sensitive and specific for prediction of a disease. However, combining multiple biomarkers may lead to better diagnostic.  The aim of this study was to assess the performance of combination of bio...

A Concise Introduction to Receiver Operating Characteristic (ROC) Curve

ROC curve analysis is used widely in medicine as a method for evaluating the performance of diagnostic tests (3,5,6,10), but has been used recently in many agricultural applications (2,4,5,11,12). The ROC curve provides information regarding how often a test’s predictions are correct, and provides a graphical method for evaluating and discriminating between different diagnostic tests or modific...

An intuitive approach to receiver operating characteristic curve analysis.

part 5: receiver operating characteristic curve and area under the curve

multiple diagnostic tools are used by emergency physicians, every day. in addition, new tools are evaluated to obtain more accurate methods and reduce time or cost of conventional ones. in the previous parts of this educational series, we described diagnostic performance characteristics of diagnostic tests including sensitivity, specificity, positive and negative predictive values, and likeliho...

Multivariate receiver-operating characteristic curve analysis: prostate cancer screening as an example.

The evolution of test performance analysis should include the long-term costs and benefits associated with testing. Evolutionary laboratory techniques to achieve this include introduction of a new methodological technique, a multivariate extension to a current analytical technique, receiver-operating characteristic (ROC) curve analysis (MultiROC analysis). This extension to ROC methodology allo...